Quats as surfactants in Pharmaceutical Suspensions

Surfactants such as Quaternary ammonium compounds (Quats) are substances that, because of their molecular structure, prefer to arrange themselves in the boundary layer (interface) between two immiscible (re. cannot be blended) phases, such as water and air, water and oil, or water and a suspension particle.

In a pharmaceutical suspension a surfactant serves two purposes:

- to increase the wettability of the drug substance
- to prevent particles from aggregating.

So an adequate surfactant is essential for obtaining a stable, homogenous and injectable suspension. Benzalkonium Chloride (BKC) can be used as a surfactant in pharmaceutical suspensions.

You can read more in the following article:

- Improving the stability of a suspension
Article from Pharmaceutical Technology Europe, February 2006

 

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